CepModBo Class Reference

This module defines data structures for Bueno-Orovio cellular activation model for cardiac electrophysiology. More...

#include <CepModBo.h>

Public Member Functions
	CepModBo ()
void	actv_strn (const double c, const double I4f, const double dt, double &gf)
	Compute macroscopic fiber strain based on sacromere force-length relationship and slow inward current variable (s) More...
void	actv_strs (const double X, const double dt, double &Tact, double &epsX)
	Compute activation force for electromechanics based on active stress model. More...
double	delta (const double r)
void	getf (const int i, const int n, const Vector< double > &X, Vector< double > &f, const double fext, Vector< double > &RPAR)
	The 'zone_id' parameter is the myocardium zone id: 1, 2 or 3. More...
void	getj (const int i, const int n, const Vector< double > &X, Array< double > &JAC)
void	init (const int nX, Vector< double > &X)
void	integ_cn2 (const int imyo, const int nX, Vector< double > &X, const double Ts, const double Ti, const double Istim, const double Ksac, Vector< int > &IPAR, Vector< double > &RPAR)
void	integ_fe (const int imyo, const int nX, Vector< double > &X, const double Ts, const double Ti, const double Istim, const double Ksac, Vector< double > &RPAR)
void	integ_rk (const int imyo, const int nX, Vector< double > &X, const double Ts, const double Ti, const double Istim, const double Ksac, Vector< double > &RPAR)
double	step (const double r)

Public Attributes
double	Vscale = 85.70
	Voltage scaling. More...
double	Tscale = 1.0
	Time scaling. More...
double	Voffset = -84.0
	Voltage offset parameter. More...
BoModelParam	u_o = {0.0, 0.0, 0.0}
BoModelParam	u_u = {1.550, 1.56, 1.61}
BoModelParam	theta_v = {0.30, 0.3, 0.3}
BoModelParam	theta_w = {0.130, 0.13, 0.13}
BoModelParam	thetam_v = {6.E-3, 0.2, 0.1}
BoModelParam	theta_o = {6.E-3, 6.E-3, 5.E-3}
BoModelParam	taum_v1 = {60.0, 75., 80.}
BoModelParam	taum_v2 = {1.15E3, 10., 1.4506}
BoModelParam	taup_v = {1.45060, 1.4506, 1.4506}
BoModelParam	taum_w1 = {60.0, 6., 70.}
BoModelParam	taum_w2 = {15.0, 140., 8.}
BoModelParam	km_w = {65.0, 200., 200.}
BoModelParam	um_w = {3.E-2, 1.6E-2, 1.6E-2}
BoModelParam	taup_w = {200.0, 280., 280.}
BoModelParam	tau_fi = {0.110, 0.1, 0.078}
BoModelParam	tau_o1 = {400.0, 470., 410.}
BoModelParam	tau_o2 = {6.0, 6., 7.}
BoModelParam	tau_so1 = {30.01810, 40., 91.}
BoModelParam	tau_so2 = {0.99570, 1.2, 0.8}
BoModelParam	k_so = {2.04580, 2., 2.1}
BoModelParam	u_so = {0.650, 0.65, 0.6}
BoModelParam	tau_s1 = {2.73420, 2.7342, 2.7342}
BoModelParam	tau_s2 = {16.0, 2., 2.}
BoModelParam	k_s = {2.09940, 2.0994, 2.0994}
BoModelParam	u_s = {0.90870, 0.9087, 0.9087}
BoModelParam	tau_si = {1.88750, 2.9013, 3.3849}
BoModelParam	tau_winf = {7.E-2, 2.73E-2, 1.E-2}
BoModelParam	ws_inf = {0.940, 0.78, 0.5}
double	Vrest = -84.0
	Resting voltage (mV) More...
double	Vcrit = -30.0
	Critical voltage (mV) More...
double	eta_T = 5.E-3
	Saturation potential. More...
double	eps_0 = 0.10
	Minimum activation (ms^{-1}) More...
double	eps_i = 1.0
	Maximum activation (ms^{-1}) More...
double	xi_T = 1.0
	Transition rate (mV^{-1}) More...
double	alFa = -4.E+6
	Active force of sacromere (-mM^{-2}) More...
double	c0 = 2.155E-4
	Resting Ca concentration (mM) := slow inward current variable (s) More...
double	mu_C = 5.E+6
	Viscous-type constant (ms-mM^{-2}) More...
double	SL0 = 1.950
	Initial length of sacromeres (um) More...
double	SLmin = 1.70
	Min. length of sacromeres (um) More...
double	SLmax = 2.60
	Max. length of sacromeres (um) More...
double	f0 = -4333.6183355821190
	Fourier coefficients. More...
double	fc1 = 2570.3953553521950
double	fs1 = -2051.8272789919760
double	fc2 = 1329.536116891330
double	fs2 = 302.2167845582220
double	fc3 = 104.9437703051160
double	fs3 = 218.3751742294220
double	Cm = 1.0
	Cm: Cell capacitance per unit surface area. More...
double	sV = 1.0
	sV: Surface to volume ratio More...
double	rho = 1.0
	rho: Cellular resistivity More...

Detailed Description

This module defines data structures for Bueno-Orovio cellular activation model for cardiac electrophysiology.

The classes defined here duplicate the data structures in the Fortran BOMOD module defined in CEPMOD_BO.f and PARAMS_BO.f files.

Constructor & Destructor Documentation

CepModBo()

CepModBo::CepModBo

(

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Copyright (c) Stanford University, The Regents of the University of California, and others.

All Rights Reserved.

See Copyright-SimVascular.txt for additional details.

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.

Member Function Documentation

actv_strn()

void CepModBo::actv_strn	(	const double	c,
		const double	I4f,
		const double	dt,
		double &	gf
	)

Compute macroscopic fiber strain based on sacromere force-length relationship and slow inward current variable (s)

actv_strs()

void CepModBo::actv_strs	(	const double	X,
		const double	dt,
		double &	Tact,
		double &	epsX
	)

Compute activation force for electromechanics based on active stress model.

getf()

void CepModBo::getf	(	const int	i,
		const int	n,
		const Vector< double > &	X,
		Vector< double > &	f,
		const double	fext,
		Vector< double > &	RPAR
	)

The 'zone_id' parameter is the myocardium zone id: 1, 2 or 3.

Member Data Documentation

alFa

double CepModBo::alFa = -4.E+6

Active force of sacromere (-mM^{-2})

c0

double CepModBo::c0 = 2.155E-4

Resting Ca concentration (mM) := slow inward current variable (s)

Cm

double CepModBo::Cm = 1.0

Cm: Cell capacitance per unit surface area.

eps_0

double CepModBo::eps_0 = 0.10

Minimum activation (ms^{-1})

eps_i

double CepModBo::eps_i = 1.0

Maximum activation (ms^{-1})

eta_T

double CepModBo::eta_T = 5.E-3

Saturation potential.

f0

double CepModBo::f0 = -4333.6183355821190

Fourier coefficients.

mu_C

double CepModBo::mu_C = 5.E+6

Viscous-type constant (ms-mM^{-2})

rho

double CepModBo::rho = 1.0

rho: Cellular resistivity

SL0

double CepModBo::SL0 = 1.950

Initial length of sacromeres (um)

SLmax

double CepModBo::SLmax = 2.60

Max. length of sacromeres (um)

SLmin

double CepModBo::SLmin = 1.70

Min. length of sacromeres (um)

sV

double CepModBo::sV = 1.0

sV: Surface to volume ratio

Tscale

double CepModBo::Tscale = 1.0

Time scaling.

u_o

BoModelParam CepModBo::u_o = {0.0, 0.0, 0.0}

Model parameters (epi, endo, myo)

Todo:

[TODO:DaveP] these guys should be maps map<int,double>.

Vcrit

double CepModBo::Vcrit = -30.0

Critical voltage (mV)

Voffset

double CepModBo::Voffset = -84.0

Voltage offset parameter.

Vrest

double CepModBo::Vrest = -84.0

Resting voltage (mV)

Vscale

double CepModBo::Vscale = 85.70

Voltage scaling.

xi_T

double CepModBo::xi_T = 1.0

Transition rate (mV^{-1})

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The documentation for this class was generated from the following files:

• svFSI/CepModBo.h
• svFSI/CepModBo.cpp